Genetic Evaluation of Men (GEM)

Objectives:

1. Collect detailed family cancer histories, personal medical history, prostate cancer
clinical features, and exposure history from men with prostate cancer and men without
prostate cancer to support studies focused on identifying hereditary cancer syndromes
and genetic/epidemiologic factors predisposing to prostate cancer susceptibility.

2. Collect behavioral measures to support research focused on assessing the needs of men
undergoing cancer risk evaluation and satisfaction with the process.

3. Create and maintain a biospecimen bank with specimens from men with prostate cancer and
without prostate cancer to support studies focused on genetic alterations predisposing
to prostate cancer risk.

4. Perform targeted and broad-scale genetic and genomic sequencing to detect genetic
alterations related to prostate cancer risk.

5. Develop mechanisms to recontact participants with updates on research genetic results to
guide genetic testing for inherited prostate cancer risk.

Inclusion Criteria:

1. Men with a personal history of prostate cancer

2. Unaffected males who are at higher risk for prostate cancer

Exclusion Criteria:

1. Age < 18 years

2. Mental or cognitive impairment that interferes with ability to provide informed
consent

3. Social circumstances that may impair the ability to follow through with study or
provide informed consent (such as homelessness, drug/alcohol dependence, etc.)