Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes



Status:Completed
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:2/13/2019
Start Date:September 19, 2017
End Date:January 29, 2019

Use our guide to learn which trials are right for you!

Efficacy and Safety of Fast-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec With or Without Metformin in Adults With Type 2 Diabetes (Onset® 9)

The study compares 2 medicines for type 2 diabetes: fast-acting insulin aspart (a new
medicine) and NovoRapid®/NovoLog® (a medicine doctors can already prescribe). Fast-acting
insulin aspart will be tested to see how well it works and if it is safe. Participants will
get either fast-acting insulin aspart or NovoRapid®/ NovoLog® - which treatment you get is
decided by chance. Both medicines will be taken together with insulin degludec. Participants
will need to take 1 injection 4 times every day (all insulins will be provided in pens). The
study will last for about 8 months (34 weeks).


Inclusion Criteria: - Male or female, age equal to or above 18 years at the time of signing
informed consent. - Diagnosed with type 2 diabetes mellitus for 10 years or longer prior to
screening (Visit 1). - Treated with a basal-bolus insulin regimen for 1 year or longer
prior to the day of screening (Visit 1). A basal-bolus insulin regimen is defined as basal
insulin once or twice daily and bolus insulin analogue taken with meals at least 3 times
daily. Treatment with premixed insulin or soluble insulin combination is not considered a
basal-bolus regimen. - Treated with or without oral antidiabetic drugs including extended
release formulations. - HbA1c 7.0-10.0% (both inclusive) as assessed by central laboratory
at screening (Visit 1). Exclusion Criteria: - Any of the following: myocardial infarction,
stroke, hospitalization for unstable angina or transient ischaemic attack within the past
180 days prior to the day of screening (Visit 1). - Subjects presently classified as being
in New York Heart Association (NYHA) Class IV. - Planned coronary, carotid or peripheral
artery revascularisation known on the day of screening (Visit 1). - Treatment with
injectable GLP-1 receptor agonists in a period of 90 days prior to screening (Visit 1). -
Anticipated initiation or change in concomitant medications (for more than 14 consecutive
days) known to affect weight or glucose metabolism (e.g. treatment with orlistat, thyroid
hormones, or corticosteroids).
We found this trial at
60
sites
1515
mi
from 43215
Ogden, UT
Click here to add this to my saved trials
Amarillo, Texas 79106
1078
mi
from 43215
Amarillo, TX
Click here to add this to my saved trials
Asheville, North Carolina 28801
302
mi
from 43215
Asheville, NC
Click here to add this to my saved trials
Atlanta, Georgia 30318
436
mi
from 43215
Atlanta, GA
Click here to add this to my saved trials
Austin, Texas 78731
1065
mi
from 43215
Austin, TX
Click here to add this to my saved trials
Beaumont, Texas 77701
925
mi
from 43215
Beaumont, TX
Click here to add this to my saved trials
Bennington, Vermont 05201
547
mi
from 43215
Bennington, VT
Click here to add this to my saved trials
Boynton Beach, Florida 33472
943
mi
from 43215
Boynton Beach, FL
Click here to add this to my saved trials
Bradenton, Florida 34201
868
mi
from 43215
Bradenton, FL
Click here to add this to my saved trials
?
mi
from 43215
Caba,
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
353
mi
from 43215
Chapel Hill, NC
Click here to add this to my saved trials
Chattanooga, Tennessee 37404
362
mi
from 43215
Chattanooga, TN
Click here to add this to my saved trials
Chesapeake, Virginia 23321
418
mi
from 43215
Chesapeake, VA
Click here to add this to my saved trials
Chicago, Illinois 60612
274
mi
from 43215
Chicago, IL
Click here to add this to my saved trials
Concord, California 94520
2081
mi
from 43215
Concord, CA
Click here to add this to my saved trials
Dallas, Texas 75231
905
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
Denver, Colorado 80220
1161
mi
from 43215
Denver, CO
Click here to add this to my saved trials
Des Moines, Iowa 50314
565
mi
from 43215
Des Moines, IA
Click here to add this to my saved trials
Fort Lauderdale, Florida 33316
972
mi
from 43215
Fort Lauderdale, FL
Click here to add this to my saved trials
Fresno, California 93702
1988
mi
from 43215
Fresno, CA
Click here to add this to my saved trials
Fullerton, California 92835
1960
mi
from 43215
Fullerton, CA
Click here to add this to my saved trials
Golden, Colorado 80401
1174
mi
from 43215
Golden, CO
Click here to add this to my saved trials
Green Bay, Wisconsin 54303
405
mi
from 43215
Green Bay, WI
Click here to add this to my saved trials
Greenville, South Carolina 29607
354
mi
from 43215
Greenville, SC
Click here to add this to my saved trials
Henderson, Nevada 89052
1755
mi
from 43215
Henderson, NV
Click here to add this to my saved trials
Honolulu, Hawaii 96814
4501
mi
from 43215
Honolulu, HI
Click here to add this to my saved trials
Lancaster, California 93534
1950
mi
from 43215
Lancaster, CA
Click here to add this to my saved trials
Las Vegas, Nevada 89128
1762
mi
from 43215
Las Vegas, NV
Click here to add this to my saved trials
Lawrenceville, Georgia 30046
418
mi
from 43215
Lawrenceville, GA
Click here to add this to my saved trials
Lexington, Kentucky 40503
157
mi
from 43215
Lexington, KY
Click here to add this to my saved trials
Longview, Texas 75605
830
mi
from 43215
Longview, TX
Click here to add this to my saved trials
146
mi
from 43215
Mentor, OH
Click here to add this to my saved trials
Miami, Florida 33136
992
mi
from 43215
Miami, FL
Click here to add this to my saved trials
Nashua, New Hampshire 03063
629
mi
from 43215
Nashua, NH
Click here to add this to my saved trials
Nashville, Tennessee 37203
333
mi
from 43215
Nashville, TN
Click here to add this to my saved trials
Norco, California 92860
1938
mi
from 43215
Norco, CA
Click here to add this to my saved trials
Northport, New York 11768
512
mi
from 43215
Northport, NY
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
849
mi
from 43215
Oklahoma City, OK
Click here to add this to my saved trials
Olympia, Washington 98502
2033
mi
from 43215
Olympia, WA
Click here to add this to my saved trials
Pearland, Texas 77584
998
mi
from 43215
Pearland, TX
Click here to add this to my saved trials
Peoria, Illinois 61615
349
mi
from 43215
Peoria, IL
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19104
414
mi
from 43215
Philadelphia, PA
Click here to add this to my saved trials
Rockville, Maryland 20852
320
mi
from 43215
Rockville, MD
Click here to add this to my saved trials
Roswell, Georgia 30076
414
mi
from 43215
Roswell, GA
Click here to add this to my saved trials
Round Rock, Texas 78681
1052
mi
from 43215
Round Rock, TX
Click here to add this to my saved trials
Sacramento, California 95821
2043
mi
from 43215
Sacramento, CA
Click here to add this to my saved trials
Seattle, Washington 98105
2006
mi
from 43215
Seattle, WA
Click here to add this to my saved trials
South Burlington, Vermont 05403
591
mi
from 43215
South Burlington, VT
Click here to add this to my saved trials
Spokane, Washington 99202
1776
mi
from 43215
Spokane, WA
Click here to add this to my saved trials
Springfield, Illinois 62702
349
mi
from 43215
Springfield, IL
Click here to add this to my saved trials
Tampa, Florida 33612
823
mi
from 43215
Tampa, FL
Click here to add this to my saved trials
Topeka, Kansas 66606
676
mi
from 43215
Topeka, KS
Click here to add this to my saved trials
Valparaiso, Indiana 46383
235
mi
from 43215
Valparaiso, IN
Click here to add this to my saved trials
Ventura, California 93003
2017
mi
from 43215
Ventura, CA
Click here to add this to my saved trials
Walnut Creek, California 94598
2084
mi
from 43215
Walnut Creek, CA
Click here to add this to my saved trials
Waltham, Massachusetts 02453
633
mi
from 43215
Waltham, MA
Click here to add this to my saved trials
Waterbury, Connecticut 06708
531
mi
from 43215
Waterbury, CT
Click here to add this to my saved trials
West Seneca, New York 14224
295
mi
from 43215
West Seneca, NY
Click here to add this to my saved trials
Winchester, Virginia 22601
264
mi
from 43215
Winchester, VA
Click here to add this to my saved trials
Worcester, Massachusetts 01655
604
mi
from 43215
Worcester, MA
Click here to add this to my saved trials