Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes



Status:Completed
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:2/13/2019
Start Date:September 19, 2017
End Date:January 29, 2019

Use our guide to learn which trials are right for you!

Efficacy and Safety of Fast-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec With or Without Metformin in Adults With Type 2 Diabetes (Onset® 9)

The study compares 2 medicines for type 2 diabetes: fast-acting insulin aspart (a new
medicine) and NovoRapid®/NovoLog® (a medicine doctors can already prescribe). Fast-acting
insulin aspart will be tested to see how well it works and if it is safe. Participants will
get either fast-acting insulin aspart or NovoRapid®/ NovoLog® - which treatment you get is
decided by chance. Both medicines will be taken together with insulin degludec. Participants
will need to take 1 injection 4 times every day (all insulins will be provided in pens). The
study will last for about 8 months (34 weeks).


Inclusion Criteria: - Male or female, age equal to or above 18 years at the time of signing
informed consent. - Diagnosed with type 2 diabetes mellitus for 10 years or longer prior to
screening (Visit 1). - Treated with a basal-bolus insulin regimen for 1 year or longer
prior to the day of screening (Visit 1). A basal-bolus insulin regimen is defined as basal
insulin once or twice daily and bolus insulin analogue taken with meals at least 3 times
daily. Treatment with premixed insulin or soluble insulin combination is not considered a
basal-bolus regimen. - Treated with or without oral antidiabetic drugs including extended
release formulations. - HbA1c 7.0-10.0% (both inclusive) as assessed by central laboratory
at screening (Visit 1). Exclusion Criteria: - Any of the following: myocardial infarction,
stroke, hospitalization for unstable angina or transient ischaemic attack within the past
180 days prior to the day of screening (Visit 1). - Subjects presently classified as being
in New York Heart Association (NYHA) Class IV. - Planned coronary, carotid or peripheral
artery revascularisation known on the day of screening (Visit 1). - Treatment with
injectable GLP-1 receptor agonists in a period of 90 days prior to screening (Visit 1). -
Anticipated initiation or change in concomitant medications (for more than 14 consecutive
days) known to affect weight or glucose metabolism (e.g. treatment with orlistat, thyroid
hormones, or corticosteroids).
We found this trial at
60
sites
Rockville, Maryland 20852
?
mi
from
Rockville, MD
Click here to add this to my saved trials
Amarillo, Texas 79106
?
mi
from
Amarillo, TX
Click here to add this to my saved trials
Asheville, North Carolina 28801
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Atlanta, Georgia 30318
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Austin, Texas 78731
?
mi
from
Austin, TX
Click here to add this to my saved trials
Beaumont, Texas 77701
?
mi
from
Beaumont, TX
Click here to add this to my saved trials
Bennington, Vermont 05201
?
mi
from
Bennington, VT
Click here to add this to my saved trials
Boynton Beach, Florida 33472
?
mi
from
Boynton Beach, FL
Click here to add this to my saved trials
Bradenton, Florida 34201
?
mi
from
Bradenton, FL
Click here to add this to my saved trials
?
mi
from
Caba,
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
Chattanooga, Tennessee 37404
?
mi
from
Chattanooga, TN
Click here to add this to my saved trials
Chesapeake, Virginia 23321
?
mi
from
Chesapeake, VA
Click here to add this to my saved trials
Chicago, Illinois 60612
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Concord, California 94520
?
mi
from
Concord, CA
Click here to add this to my saved trials
Dallas, Texas 75231
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Denver, Colorado 80220
?
mi
from
Denver, CO
Click here to add this to my saved trials
Des Moines, Iowa 50314
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
Fort Lauderdale, Florida 33316
?
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
Fresno, California 93702
?
mi
from
Fresno, CA
Click here to add this to my saved trials
Fullerton, California 92835
?
mi
from
Fullerton, CA
Click here to add this to my saved trials
Golden, Colorado 80401
?
mi
from
Golden, CO
Click here to add this to my saved trials
Green Bay, Wisconsin 54303
?
mi
from
Green Bay, WI
Click here to add this to my saved trials
Greenville, South Carolina 29607
?
mi
from
Greenville, SC
Click here to add this to my saved trials
Henderson, Nevada 89052
?
mi
from
Henderson, NV
Click here to add this to my saved trials
Honolulu, Hawaii 96814
?
mi
from
Honolulu, HI
Click here to add this to my saved trials
Lancaster, California 93534
?
mi
from
Lancaster, CA
Click here to add this to my saved trials
Las Vegas, Nevada 89128
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Lawrenceville, Georgia 30046
?
mi
from
Lawrenceville, GA
Click here to add this to my saved trials
Lexington, Kentucky 40503
?
mi
from
Lexington, KY
Click here to add this to my saved trials
Longview, Texas 75605
?
mi
from
Longview, TX
Click here to add this to my saved trials
?
mi
from
Mentor, OH
Click here to add this to my saved trials
Miami, Florida 33136
?
mi
from
Miami, FL
Click here to add this to my saved trials
Nashua, New Hampshire 03063
?
mi
from
Nashua, NH
Click here to add this to my saved trials
Nashville, Tennessee 37203
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Norco, California 92860
?
mi
from
Norco, CA
Click here to add this to my saved trials
Northport, New York 11768
?
mi
from
Northport, NY
Click here to add this to my saved trials
?
mi
from
Ogden, UT
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Olympia, Washington 98502
?
mi
from
Olympia, WA
Click here to add this to my saved trials
Pearland, Texas 77584
?
mi
from
Pearland, TX
Click here to add this to my saved trials
Peoria, Illinois 61615
?
mi
from
Peoria, IL
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19104
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Roswell, Georgia 30076
?
mi
from
Roswell, GA
Click here to add this to my saved trials
Round Rock, Texas 78681
?
mi
from
Round Rock, TX
Click here to add this to my saved trials
Sacramento, California 95821
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
Seattle, Washington 98105
?
mi
from
Seattle, WA
Click here to add this to my saved trials
South Burlington, Vermont 05403
?
mi
from
South Burlington, VT
Click here to add this to my saved trials
Spokane, Washington 99202
?
mi
from
Spokane, WA
Click here to add this to my saved trials
Springfield, Illinois 62702
?
mi
from
Springfield, IL
Click here to add this to my saved trials
Tampa, Florida 33612
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Topeka, Kansas 66606
?
mi
from
Topeka, KS
Click here to add this to my saved trials
Valparaiso, Indiana 46383
?
mi
from
Valparaiso, IN
Click here to add this to my saved trials
Ventura, California 93003
?
mi
from
Ventura, CA
Click here to add this to my saved trials
Walnut Creek, California 94598
?
mi
from
Walnut Creek, CA
Click here to add this to my saved trials
Waltham, Massachusetts 02453
?
mi
from
Waltham, MA
Click here to add this to my saved trials
Waterbury, Connecticut 06708
?
mi
from
Waterbury, CT
Click here to add this to my saved trials
West Seneca, New York 14224
?
mi
from
West Seneca, NY
Click here to add this to my saved trials
Winchester, Virginia 22601
?
mi
from
Winchester, VA
Click here to add this to my saved trials
Worcester, Massachusetts 01655
?
mi
from
Worcester, MA
Click here to add this to my saved trials