Stress-Busting Program and QoL, Bio-markers of Immunity/Stress and Cellular Aging

The overarching goal of this project is to (1) explore the differences in quality of life
(QoL), inflammation, stress, telomere length, and mucosal immune function of Hispanic
caregivers of persons with ADRD and (2) determine whether a caregiver intervention can
effectively improve the QoL, inflammation, stress, telomere length, and mucosal immune
function biomarkers of Hispanic caregivers.

The proposed study is a non-randomized trial design with three groups of ADRD caregivers that
vary based on Hispanic ethnicity and English/Spanish language preference. The project's
specific aims are:

Specific Aim 1: To compare the quality of life (QoL) (stress, depression, and burden),
mucosal immunity function (sIgA), stress (sCortisol and sAmylase), inflammation(CRP), and
telomere length in Spanish-speaking Hispanic, English-speaking Hispanic, and English-speaking
non-Hispanic caregivers who participate in an evidence-based Stress-Busting Program (SBP) for
family caregivers of family members living with ADRD. Working hypothesis: At baseline,
Spanish-speaking Hispanic caregivers have lower QoL and immune function, higher levels of
inflammation and stress, and shorter telomeres as compared to Hispanic and non-Hispanic
English-speaking caregivers.

Specific Aim 2: To compare the impact of the SBP on QoL and biomarkers for stress, aging,
inflammation and mucosal immunity among those caregivers completing the SBP (Hispanic
caregivers completing the culturally adapted translated version to Spanish of SBP and
Hispanic and non-Hispanic caregivers completing the English-SBP). Working Hypothesis:
Spanish-speaking Hispanic caregivers completing the Spanish-SBP show more improvement in
their QoL and biomarkers of stress, mucosal immunity, aging and inflammation
post-intervention as compared to Hispanic and Non-Hispanic caregivers completing the
English-SBP. To achieve these aims, the investigators propose to deliver the 9-week English
SBP and the translated and culturally adapted Spanish-SBP. Saliva and blood samples and self-
report measures of QoL will be collected at baseline and 9 weeks (end of intervention)

Inclusion Criteria:

1. self-identified caregiver for a person living with ADRD. Family caregivers of people
with ADRD include spouses, adult children, grandchildren, siblings, partners, and
significant others.

In addition to Alzheimer's disease, other causes of dementia include multiple
sclerosis, Parkinson's, post-traumatic stress disorder (PTSD), and/or traumatic brain
injury (TBI),

2. over the age of 18,

3. those wishing to participate in the Spanish SBP must speak and read Spanish.

Exclusion Criteria:

- Speaking a language other than English or Spanish

- Caring for an individual not diagnosed with a cognitive impairment as delineated in
inclusion criteria.