Effects of rTMS on Human Brain Activity Measured With EEG and fMRI
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 30 |
| Updated: | 11/18/2018 |
| Start Date: | January 12, 2018 |
| End Date: | September 1, 2021 |
| Contact: | Alexandra C Brito, BA |
| Email: | alexandra.brito@duke.edu |
| Phone: | 919-668-1321 |
This project investigates the effects of repetitive transcranial magnetic stimulation (rTMS)
on neural circuits as a function of spatiotemporal parameters and brain state in order to
better understand why the method works and how to improve its efficacy. Leveraging our
expertise in application of TMS methodology during concurrent single neuron recording
techniques in non-human primates and imaging and scalp potential techniques in humans (fMRI
and EEG), the investigators aim to resolve three interlocking problems in the design and
application of rTMS: stimulation frequency, spatial targeting, and interactions with brain
state.
on neural circuits as a function of spatiotemporal parameters and brain state in order to
better understand why the method works and how to improve its efficacy. Leveraging our
expertise in application of TMS methodology during concurrent single neuron recording
techniques in non-human primates and imaging and scalp potential techniques in humans (fMRI
and EEG), the investigators aim to resolve three interlocking problems in the design and
application of rTMS: stimulation frequency, spatial targeting, and interactions with brain
state.
Inclusion Criteria:
1. Age between 18-30.
2. Use of effective method of birth control for women of childbearing capacity.
3. Willing to provide informed consent.
Exclusion Criteria:
1. Current or recent (within the past 6 months) of substance abuse or dependence,
excluding nicotine and caffeine (urine test).
2. Current serious medical illness (self report).
3. History of seizure except those therapeutically induced by ECT (childhood febrile
seizures are acceptable and these subjects may be included in the study), history of
epilepsy in self or first degree relatives, stroke, brain surgery, head injury,
cranial metal implants, known structural brain lesion, devices that may be affected by
rTMS or MRI (pacemaker, medication pump, cochlear implant, implanted brain
stimulator); [TMS Adult Safety Screening (TASS) form].
4. Subjects are unable or unwilling to give informed consent.
5. Diagnosed any Axis I DSM-IV disorder (MINI, DSM-IV)
6. Subjects with a clinically defined neurological disorder including, but not limited
to:
1. Any condition likely to be associated with increased intracranial pressure
2. Space occupying brain lesion.
3. History of stroke.
4. Transient ischemic attack within two years.
5. Cerebral aneurysm.
6. Dementia.
7. Mini Mental Status Exam (MMSE) score of <24.
8. Parkinson's disease.
9. Huntington's disease.
i. Multiple sclerosis.
7. Increased risk of seizure for any reason, including prior diagnosis of increased
intracranial pressure (such as after large infarctions or trauma), or currently taking
medication that lowers the seizure threshold.
8. Subjects with cochlear implants
9. Subjects not willing to tolerate the confinement associated with being in the MRI
scanner.
10. Women who are pregnant or breast-feeding (urine test).
11. Blindness.
12. Inability to read or understand English.
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