Cognitive Training Intervention and Attitudes Towards Genetics

The investigators propose using an "off-the-shelf" product - Lumosity
(http://www.lumosity.com/) - an online cognitive training program, to address the cognitive
impairment in outpatient HCT survivors. The program offers over 60 tasks in game-like format
that cover the main cognitive domains: processing speed, working memory, and executive
function. Training will involve a daily session of 5 training tasks for 12 weeks. Each time
the patient is logged in for a session, a customized report will be generated by the Lumosity
program to capture performance information.

Ideally, targeting the intervention and offering it specifically to those at highest risk
(integrating clinical and genetic markers) would ensure efficacy. However, evidence is
lacking on whether patients are receptive to communication of individual genetic information
and whether provision of such results would lead to enhanced intervention response. To
realize the high expectations of personalized medicine, patients' preferences and attitudes
need to be thoroughly investigated especially as more information on genetic risk becomes
available. The investigators will examine patients' genetic knowledge to determine whether
factual knowledge of genetics is essential for understanding genetic risk and for informing
treatment decision making in this patient population.

Inclusion Criteria:

- ≥ 21 years old at time of allogeneic HCT performed at UAB

- Outpatient and between 3 and 6 months post HCT

- English speaking

- Possess access to an internet-connected home computer

Exclusion criteria:

- History of pre-existing neurological disorder or documented major psychiatric
disorder; significant auditory, visual, or motor impairments

- Participated in neuropsychological intervention within the past 6 months

- History of color blindness