Topical Treatment and Prevalence of P. Acnes
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/19/2018 |
| Start Date: | September 11, 2017 |
| End Date: | January 1, 2018 |
Pre-operative Topical Treatment and the Prevalence of Propionibacterium Acnes
This study is about preventing surgical site infections of the shoulder. We hope to learn if
clindamycin alone, benzoyl peroxide alone, or clindamycin and benzoyl peroxide together can
affect growth of Propionibacterium acnes in the dermal layer.
clindamycin alone, benzoyl peroxide alone, or clindamycin and benzoyl peroxide together can
affect growth of Propionibacterium acnes in the dermal layer.
P. acnes are skin pathogens known to cause surgical site infections despite proper
preoperative surgical preparation. Lee et al. showed 70% growth rate of P. acnes despite the
application of Choraprep prior to sampling. However, this study was limited as it failed to
utilize a control group and only investigated one preparatory technique. Meanwhile, there
remains to date no study investigating the effect of topical treatments. The purpose of this
study is to investigate how specific topical treatments affect growth in the dermal layer. 12
volunteers who are normal volunteers, students, or employees of USC will each receive 4 punch
biopsies from their back above the scapular spine, with each biopsy taken from a region of
the skin treated with a different topical (topical clindamycin alone, topical benzoyl
peroxide alone, topical clindamycin and benzoyl peroxide together, and a control). A 3df
overall test of the treatment indicators will test for any differences in positivity for P
Acnes among the treatments; pairwise comparisons among the treatments will adjust for
multiple comparisons. A two-tailed statistical test will be performed, testing at an alpha of
0.05, and analyses will also be performed based on hemolytic subtypes.
preoperative surgical preparation. Lee et al. showed 70% growth rate of P. acnes despite the
application of Choraprep prior to sampling. However, this study was limited as it failed to
utilize a control group and only investigated one preparatory technique. Meanwhile, there
remains to date no study investigating the effect of topical treatments. The purpose of this
study is to investigate how specific topical treatments affect growth in the dermal layer. 12
volunteers who are normal volunteers, students, or employees of USC will each receive 4 punch
biopsies from their back above the scapular spine, with each biopsy taken from a region of
the skin treated with a different topical (topical clindamycin alone, topical benzoyl
peroxide alone, topical clindamycin and benzoyl peroxide together, and a control). A 3df
overall test of the treatment indicators will test for any differences in positivity for P
Acnes among the treatments; pairwise comparisons among the treatments will adjust for
multiple comparisons. A two-tailed statistical test will be performed, testing at an alpha of
0.05, and analyses will also be performed based on hemolytic subtypes.
Inclusion Criteria:
- healthy volunteer
- age > 18
Exclusion Criteria:
- history of antibiotic use in the last month
- active acne on the back
- non-English speakers (the study personnel do not have adequate training to converse
and consent in other languages)
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