Pharyngeal Anatomy In Obstructive Sleep Apnea With HRM

High-resolution pharyngeal manometry (HRM) is a diagnostic technique that has the potential
to objectively measure pharyngeal collapse patterns in obstructive sleep apnea (OSA) during
sedation as well as natural sleep. The purpose of this study is to assess the utility of HRM
in objectively mapping patterns of pharyngeal collapse observed during drug-induced sleep
endoscopy (DISE). Quantifying pharyngeal collapse patterns that occur during sedation and in
natural sleep may significantly impact the selection and success of surgical treatments, as
well as surgical outcome assessment.

Inclusion Criteria:

- Adult patient (≥18 years old)

- A diagnosis of obstructive sleep apnea as determined by polysomnogram with an
apnea-hypopnea index of ≥ 5.0/hr

- Intolerant of continuous positive airway pressure (CPAP) therapy due to physical or
psychosocial limitations as determined by PI

- Scheduled to undergo DISE as part of routine clinical assessment for further
evaluation of pharyngeal anatomy

Exclusion Criteria:

- Patient is unable to consent for research due to a pre-existing neurologic condition
as determined by PI

- Patient is unable to consent for research due to language barriers

- Patient has a history of egg allergy as determined by history or self- report

- Patient is pregnant as determined by patient report or preoperative anesthesia
evaluation

- Cardiopulmonary or other medical conditions precluding safe sedation as determined by
clinical history and exam

- History of palatal or pharyngeal airway surgery except tonsillectomy as determined by
clinical history and exam

- History of radiation treatment to the head or neck as determined by clinical history
and/or exam

- Severe nasal airway obstruction preventing simultaneous flexible nasopharyngoscopy and
manometry probe insertion as determined by physical exam