Understanding the Late Effects of Surviving a Pediatric Brain Tumor

Inclusion Criteria:

Children Treated for Posterior Fossa Tumors:

- As per medical record or clinical report, successfully completed all medical treatment
for either an M0 posterior fossa medulloblastoma without dissemination or posterior
fossa low-grade astrocytoma without relapse or evidence of residual disease.

- For medulloblastoma survivors only: Previously treated with gross total resection
(GTR), craniospinal irradiation with conformal posterior fossa boost radiotherapy (CSI
+ Boost) and chemotherapy

- For low grade astrocytoma survivors only: Previously treated with gross total
resection ONLY (no chemotherapy or radiotherapy).

- As per medical record or clinician report, between 1-10 years post completion of their
medical treatment for their posterior fossa brain tumor.

- Subject is between the ages of 6 through 16 years at time of consent.

- As per medical record or parent report, subject is able to tolerate an MRI without
sedation.

Healthy Control Participants:

- No major medical illness, as determined by medical interview by study physician.

- As per parent report, subject is between the ages of 6 through 16 years at time of
consent.

- As per parent report, subject is able to tolerate an MRI without sedation.

Exclusion Criteria:

All Participants:

- Full Scale IQ as documented to be below a standard score of <70 based upon the study
IQ assessment completed after consent.

- As per self or parent report, completed any portion of the neuropsychological battery
used in this study within the last year.

- MRI contraindications (e.g., implanted ferromagnetic devices, claustrophobia) as per
radiology clinical operating procedures.

- As per self or parent report or medical record, currently taking medications that have
CNS effects (i.e., antidepressants, neuroleptics, anti-seizure medications, drugs that
affect blood pressure or heart rate, alpha-agonists, adrenergic blockers, lithium,
sedating antihistamines, and some medications for the treatment of asthma).

- As per self or parent report, non-fluency in English language as demonstrated by
current educational placement in a non-English-speaking classroom setting.