Physical Exercise And Cognitive Engagement Outcomes for Mild Neurocognitive Disorder



Status:Recruiting
Conditions:Cognitive Studies, Neurology
Therapuetic Areas:Neurology, Psychiatry / Psychology
Healthy:No
Age Range:21 - Any
Updated:3/21/2019
Start Date:March 23, 2017
End Date:March 2020
Contact:Glenn E. Smith, Ph.D.
Email:glennsmith@phhp.ufl.edu
Phone:352-273-6556

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria
Behavioral interventions currently provide the most useful approach to addressing the
behavioral and social needs of those with Mild Cognitive Impairment (MCI) due to Alzheimer's
or other diseases. This randomized, multisite, 3-arm study will investigate the impact of
computerized brain fitness vs yoga vs an active control group (wellness education) on changes
in cognitive function, daily functioning and quality of life in persons with Mild Cognitive
Impairment (MCI) and their partner. In addition, in vivo neuroimaging measures of plasticity
during the pre- and post-intervention periods will be measured and compared between the three
different treatment groups. These neuroimaging measures of plasticity will be investigated in
their relationship to the cognitive outcomes within each group.


For the patients diagnosed with MCI:

Inclusion Criteria:

1. Written informed consent for participation. Patient also needs to sign a legally
authorized representative (LAR) addendum should MCI patient become incapacitated

2. A diagnosis of amnestic MCI (single domain or multi-domain)

3. A Clinical Dementia Rating scale score of 0 or 0.5

4. At least 50.

5. Either not taking or stable on nootropic(s) and/or pain medication for at least 3
months.

6. Fluent in English.

7. A score of at least 25 on the Telephone Interview for Cognitive Status for Memory.

Exclusion Criteria:

1. MRI contraindications (e.g., ferrous metal in the body, claustrophobia, pregnancy)

2. Physical impairments, language comprehension deficits, or significant hearing
disturbances that would limit ability to perform tasks or participation in the
intervention.

For the care partners:

Inclusion Criteria:

1. Written informed consent for participation.

2. At least 21 years of age.

3. A score of at least 32 on the Telephone Interview for Cognitive Status for Memory.

4. Partner has at least twice-weekly contact with the participant.

Exclusion Criteria:

1. Physical impairments, language comprehension deficits, or significant hearing
disturbances that would limit ability to perform tasks or participation in the
intervention.
We found this trial at
1
site
University of Florida
Gainesville, Florida 32610
(352) 392-3261
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
?
mi
from
Gainesville, FL
Click here to add this to my saved trials