A Study of the Efficacy of ONS to Reduce Postoperative Complications Associated With Pancreatic Surgery

Patients undergoing pancreatic surgery for either chronic pancreatitis or known/suspected
pancreatic cancer represent the study population for this clinical trial.

Study subjects randomized to one of the ONS arms will be asked to consume the drink during
the study intervention. Study visits immediately preoperative, and 1, 3, and 6 months
following surgery will be in-person visits. If subjects are unable to return to our
Institution for subsequent clinical care, these telephone interviews will be collected and
acquisition of locally obtained laboratory tests will be attempted.

Assessments performed during postoperative visits include:

- Vital signs and physical examination

- Blood samples

- Performance status and strength

- Quality of life measures

- Postoperative complications and hospital readmissions (if any)

Inclusion Criteria:

1. Age 40-89 at the time of study enrollment.

2. Undergoing pancreatectomy for either chronic pancreatitis or pancreatic cancer.

3. Ability and willingness to complete study related documents and activities.

Exclusion Criteria:

1. Severe malnutrition that in the judgment of the patient's supervising physician or an
investigator would not permit surgical intervention without preoperative nutritional
support (enteral or parenteral).

2. Subject is receiving (or planned to receive) enteral tube feeding or parenteral
nutrition at the time of screening or before surgery.

3. Surgery is planned within 7 days of enrollment (i.e., inadequate time to offer the
study intervention).

4. Known allergy to soy or milk, which are included in the oral supplement.

5. The inability to refrain from using a non-study oral nutritional supplement or fish
oil supplementation (unless prescribed for treatment of hyperlipidemia).

6. Pregnancy, incarceration, or inability to provide written informed consent.