Phase I Study of KRN330 Monoclonal Antibody in Patients With Colorectal Cancer

Inclusion Criteria:

1. Have histologically confirmed colorectal cancer that is advanced or metastatic with
measurable or assessable disease.

2. Are not candidates for a surgically curative procedure.

3. Have progressed despite, are intolerant of, or are not appropriate for current
therapies.

Exclusion Criteria:

1. Have an active, uncontrolled infection.

2. Have known or suspected cerebral metastasis.

3. Have had a myocardial infarction (MI) or cerebrovascular accident (CVA) within the
last 6 months; or meet the criteria for AHA class III or IV congestive heart failure
(CHF).

4. Have any significant concurrent disease or illness that would interfere with the
interpretation of study results.

5. Pregnant or breastfeeding women and male or female patients who do not agree to use
effective contraceptive method(s) during the study.