Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome
| Status: | Enrolling by invitation |
|---|---|
| Healthy: | No |
| Age Range: | 3 - 12 |
| Updated: | 8/19/2018 |
| Start Date: | September 2016 |
| End Date: | July 2021 |
Non-inferiority Prospective Randomized Trial of Acetazolamide Versus Diazepam in Patients With Continuous Spike and Wave in Sleep (CSWS)/Landau Kleffner Syndrome (LKS)
The purpose of this study is to compare the effectiveness of the medications acetazolamide
and diazepam in the treatment of continuous spike wave in sleep (CSWS) and Landau-Kleffner
syndrome (LKS).
and diazepam in the treatment of continuous spike wave in sleep (CSWS) and Landau-Kleffner
syndrome (LKS).
Inclusion Criteria:
- ESES and clinical CSWS/LKS defined by all of the following:
- SWI ≥50% during first hour of sleep
- Bilateral synchrony of discharges during sleep
- Clinical evidence of behavior and/or academic regression
- Daytime SWI ≤20%
Exclusion Criteria:
- Previous treatment with benzodiazepine or acetazolamide for Electrical Status
Epilepticus in Sleep (ESES)
- Current treatment with carbamazepine, phenytoin, oxcarbazepine, phenobarbital,
vigabatrin or lamotrigine
- Antiepileptic medication changes over the month prior to enrollment
- Epileptic encephalopathy other than CSWS/LKS
- Prior serious adverse reaction to benzodiazepines or acetazolamide
- Sulfa allergy
- Progressive underlying neurologic condition
- Frequent seizures that would prevent the patient from maintaining a stable dose of
medications
- Female patient that has begun menses or is pregnant
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