Paleolithic Diets vs T2D and Improvements in the Metabolic Syndrome

This study proposes to evaluate the physiological effects of eating Paleolithic type diet
("hunter-gatherer's diet") on Type 2 diabetic patients. The diet essentially consists of
fruits, vegetables, nuts, lean meats, excludes dairy products and grains.Subjects will be
randomized into taking either ADA (American Diabetic Association) recommended diet or
Paleolithic diet for 21 days. The research kitchen will provide all food items and total
calories in both groups will be adjusted to maintain baseline weight. Blood and urine test
will be done in the first 3 days, last 3 days and 1 month after the study period to study
and compare the effects of the two diets on subjects glucose control, lipid profile and
other parameters of cardiovascular physiology.

We hypothesize that a palaeolithic diet in subjects with Type 2 diabetes mellitis, will
result in improvement in above parameters and lead to improvement in glucose control with
less need for diabetes medicines (either lower doses or fewer medications) to a greater
extent than in subjects fed with ADA diet, without any change in weight. We also expect a
beneficial effect on blood vessel function, lipid profiles and blood pressure.