In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants



Status:Completed
Conditions:Obesity Weight Loss, Neurology, Women's Studies
Therapuetic Areas:Endocrinology, Neurology, Reproductive
Healthy:No
Age Range:Any
Updated:9/28/2017
Start Date:July 1996
End Date:June 2000

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In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight (ELBW) Infants

This study examined the effect of magnesium sulfate (MgSO4) exposure on adverse outcome in
extremely low birth weight (ELBW) infants. For infants included in the NICHD Neonatal
Research Network Generic Database whose mothers were given prenatal MgSO4, data were
prospectively collected on maternal/infant conditions and magnesium exposure (including
indications, timing and duration of exposure).

Retrospective studies suggested that the risk of cerebral palsy and intraventricular
hemorrhage (IVH) in extremely premature infants of mothers given magnesium sulfate (MgSO4)
may be reduced. The purpose of this study was to examine the effects of MgSO4 exposure on
adverse outcomes in extremely low birth weight (ELBW) infants. For infants included in the
NICHD Neonatal Research Network Generic Database, data were prospectively collected on
maternal/infant conditions and MgSO4 exposure (including indications, timing and duration of
exposure).

Inclusion Criteria:

- Infants born in NRN Centers with a birth weight of 401-1,500g

Exclusion Criteria:
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920 Madison Ave
Memphis, Tennessee 38163
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201 Dowman Dr
Atlanta, Georgia 30303
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1720 2nd Ave S
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Cambridge, Massachusetts 02138
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5323 Harry Hines Blvd
Dallas, Texas 75235
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5050 Anthony Wayne Dr
Detroit, Michigan 48201
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425 University Blvd.
Indianapolis, Indiana 46202
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Miami, Florida 33124
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New Haven, Connecticut 6520
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Palo Alto, California 94304
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Washington, D.C., District of Columbia 20052
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