Delayed Cord Clamping in VLBW Infants
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 9/28/2017 |
| Start Date: | June 2000 |
| End Date: | December 2000 |
Delayed Cord Clamping in VLBW Infants Pilot Study
This study tested the feasibility of conducting a randomized controlled trial to vary the
timing that doctors clamp the umbilical cord after birth in extremely low birthweight
infants. The study also tested whether delaying cord clamping by 30-35 seconds and holding
the newborn approximately 10 inches below the birth canal would result in increased
hematocrit at 4 hours of age.
timing that doctors clamp the umbilical cord after birth in extremely low birthweight
infants. The study also tested whether delaying cord clamping by 30-35 seconds and holding
the newborn approximately 10 inches below the birth canal would result in increased
hematocrit at 4 hours of age.
This study tested the hypothesis that delaying clamping of the umbilical cord in extremely
low birthweight (ELBW) infants would result in additional blood transfusion from the placenta
to the baby, increasing the infant's blood volume and blood pressure. Higher blood pressure
may improve blood flow to the brain that may reduce potential the risk of hypoxic ischemic
encephalopathy (HIE) and/or intraventricular hemorrhage (IVH). The additional placental flow
may also increase the amount of stem cells and cytokines flowing to the baby, improving
immune status and reducing the risk of infection, while at the same time reducing the need
for blood transfusions in the neonatal period.
This was a pilot study to test the feasibility of having obstetricians delay cord clamping
for 30-45 seconds, and to confirm whether the procedure significantly increases the baby's
hematocrit during the first 4 hours of life.
low birthweight (ELBW) infants would result in additional blood transfusion from the placenta
to the baby, increasing the infant's blood volume and blood pressure. Higher blood pressure
may improve blood flow to the brain that may reduce potential the risk of hypoxic ischemic
encephalopathy (HIE) and/or intraventricular hemorrhage (IVH). The additional placental flow
may also increase the amount of stem cells and cytokines flowing to the baby, improving
immune status and reducing the risk of infection, while at the same time reducing the need
for blood transfusions in the neonatal period.
This was a pilot study to test the feasibility of having obstetricians delay cord clamping
for 30-45 seconds, and to confirm whether the procedure significantly increases the baby's
hematocrit during the first 4 hours of life.
Inclusion Criteria:
- Infants born at participating centers at 24-27 weeks gestation
- Singletons
- Obstetrician approval for enrollment
- Parental consent
Exclusion Criteria:
- Prenatally diagnosed major congenital anomalies
- Intent to withhold or withdraw care
- Significant bleeding due to placenta previa or abruption
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