WTC Chest CT Imaging Archive
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Lung Cancer, Lung Cancer, Cancer, Chronic Obstructive Pulmonary Disease, Pulmonary, Pulmonary |
| Therapuetic Areas: | Oncology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/8/2018 |
| Start Date: | January 15, 2013 |
| End Date: | August 31, 2021 |
Pulmonary Diseases in WTC Workers: Symptoms, Function, and Chest CT Correlates
Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted
readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai
Medical Center between 2003 and 2016. The clinical team sought to assess all findings
suggestive of airway, interstitial, and neoplastic disease in a systematic way, and correlate
those findings with clinical, functional, and exposure indicators. The study team's research
will also involve analyses of longitudinal imaging and functional trends, and
characterization of the WTC related lower airway diseases and their risk factors, with a
focus on obesity-related imaging markers.
readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai
Medical Center between 2003 and 2016. The clinical team sought to assess all findings
suggestive of airway, interstitial, and neoplastic disease in a systematic way, and correlate
those findings with clinical, functional, and exposure indicators. The study team's research
will also involve analyses of longitudinal imaging and functional trends, and
characterization of the WTC related lower airway diseases and their risk factors, with a
focus on obesity-related imaging markers.
The goal of this proposal is to characterize WTC-related lower airway disorders, and use
novel imaging approaches to the investigation of obesity, one of their most important risk
factors for poor clinical outcome and chronicity. To that end, the clinical team will utilize
the WTC Pulmonary Evaluation Unit Chest CT Imaging Archive, an already established large
imaging database, linked to extensive related databases that include disease symptoms, both
pre-WTC and WTC-related occupational exposures, detailed pulmonary function and longitudinal
spirometry measurements, visual imaging classification and grading, and quantitative computer
assisted method (QCAM) measurements of airway, pulmonary parenchymal, pleural, and
cardiovascular abnormalities. During the course of the proposed research project, the
clinical team will continue to enrich most sources of data with periodic updates, in order to
accrue information on the trajectories of the different clinical, functional, and imaging
abnormalities observed in this population, and investigate the role of key adverse risk
factors directly, and in collaboration with other investigators.
novel imaging approaches to the investigation of obesity, one of their most important risk
factors for poor clinical outcome and chronicity. To that end, the clinical team will utilize
the WTC Pulmonary Evaluation Unit Chest CT Imaging Archive, an already established large
imaging database, linked to extensive related databases that include disease symptoms, both
pre-WTC and WTC-related occupational exposures, detailed pulmonary function and longitudinal
spirometry measurements, visual imaging classification and grading, and quantitative computer
assisted method (QCAM) measurements of airway, pulmonary parenchymal, pleural, and
cardiovascular abnormalities. During the course of the proposed research project, the
clinical team will continue to enrich most sources of data with periodic updates, in order to
accrue information on the trajectories of the different clinical, functional, and imaging
abnormalities observed in this population, and investigate the role of key adverse risk
factors directly, and in collaboration with other investigators.
Inclusion Criteria:
- All subjects will be participants in the screening/monitoring (SMP) and treatment
program (TP) sides of the WTC Health Plan Clinical Center Excellence at Mount Sinai
Medical Center, the major site, by far of the NY/NJ consortium of this program.
Exclusion Criteria:
- Special vulnerable populations, such as fetuses, neonates, pregnant women, children,
prisoners, institutionalized individuals, will not be involved in this research study.
We found this trial at
1
site
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
Click here to add this to my saved trials
