Vitamin C in Atrial Fibrillation Ablation



Status:Active, not recruiting
Conditions:Atrial Fibrillation
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:21 - Any
Updated:4/17/2018
Start Date:September 18, 2017
End Date:March 13, 2019

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Trial Summary
Trial Overview
Inclusion Criteria

Pilot Study of the Safety and Efficacy of Intravenous Vitamin C in Patients Undergoing Atrial Fibrillation Ablation

Single-center, double-blinded, randomized, controlled safety and feasibility pilot study of
high dose IV ascorbic acid (200mg/kg) over 24 hours, divided into four doses and administered
every six hours with a 30 minute IV infusion time per dose, compared to matched placebo
infusion


Inclusion Criteria:

1. Age >/= 21 years

2. Diagnosis of atrial fibrillation with plans for a catheter-based ablation procedure

3. Ability to provide informed consent and willingness to be included in the study

Exclusion Criteria:

1. Known allergy to Vitamin C

2. Inability to obtain informed consent

3. Diabetes mellitus either requiring the use of insulin therapy or not requiring the use
of insulin therapy but which is uncontrolled, defined as a glycosylated hemoglobin of
greater than or equal to 8%

4. Prior catheter-based ablation for atrial fibrillation

5. Pregnancy or breast feeding

6. Active renal calculus

7. Active acute or chronic infection (including HIV or hepatitis C)

8. Active or recent (within 5 years) malignancy

9. Autoimmune or autoinflammatory disease

10. Recent or active use of immunosuppressive medications

11. Non-English speaking

12. Ward of the state (inmate, other)
We found this trial at
1
site
Virginia Commonwealth University
Richmond, Virginia 23298
(804) 828-0100
Principal Investigator: Jay Koneru, MD
Phone: 804-628-5079
Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
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from
Richmond, VA
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