Influence of n-Acetylcysteine Maintenance on Alcohol Effects
| Status: | Recruiting |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 55 |
| Updated: | 2/2/2019 |
| Start Date: | September 15, 2017 |
| End Date: | December 14, 2019 |
| Contact: | William W Stoops, PhD |
| Email: | william.stoops@uky.edu |
| Phone: | 8592575388 |
A Human Laboratory Study of n-Acetylcysteine for Alcohol Use Disorder
This study will evaluate the behavioral effects of alcohol during placebo and
n-acetylcysteine maintenance using sophisticated human laboratory methods.
n-acetylcysteine maintenance using sophisticated human laboratory methods.
Inclusion Criteria:
- able to speak/read English
- not seeking treatment at the time of the study
- one binge drinking episode (5+/4+ standard alcoholic drinks per drinking session for
men and women, respectively) in the past 30 days
- recent alcohol use verified by ethyl glucuronide positive urine, as well as
fulfillment of DSM-5 diagnostic criteria for alcohol use disorder
- ECG within normal limits
- otherwise healthy
- body mass index of 19-35
- females using an effective form of birth control and not pregnant or breast feeding
- judged by the medical staff to be psychiatrically and physically healthy
- able to abstain from alcohol for 12 hours prior to session
- no contraindications/allergies to n-acetylcysteine
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