A Study of SC-007 in Subjects With Advanced Cancer
Status: | Terminated |
---|---|
Conditions: | Colorectal Cancer, Cancer, Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 4/29/2018 |
Start Date: | September 13, 2017 |
End Date: | April 2, 2018 |
An Open Label Study of SC-007 in Subjects With Advanced Cancer
This is a multicenter, open-label, Phase 1 study in participants with colorectal cancer (CRC)
or gastric cancer to study the safety and tolerability of SC-007 and consists of Part A (dose
regimen finding) in participants with CRC followed by Part A in participants with gastric
cancer. Part B (dose expansion) will enroll participants into separate disease specific
cohorts of CRC or gastric cancer.
or gastric cancer to study the safety and tolerability of SC-007 and consists of Part A (dose
regimen finding) in participants with CRC followed by Part A in participants with gastric
cancer. Part B (dose expansion) will enroll participants into separate disease specific
cohorts of CRC or gastric cancer.
Inclusion Criteria:
- Histologically or cytologically confirmed advanced metastatic or unresectable advanced
colorectal cancer (CRC) or gastric cancer that is relapsed, refractory, or progressive
after:
- CRC: at least 2 prior systemic regimens in the metastatic setting, and as appropriate
in patients whose tumors are microsatellite instability-high (MSI-H), pembrolizumab as
well.
- Gastric cancer (including gastric and EGJ cancers): at least 2 prior systemic regimens
in adjuvant, advanced, or metastatic setting and, as appropriate, a human epidermal
growth factor receptor 2 (HER2) targeted agent.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Adequate hematologic, hepatic, and renal function.
Exclusion Criteria:
- Any significant medical condition that, in the opinion of the investigator or sponsor,
may place the participant at undue risk from the study.
- Has electrocardiogram (ECG) abnormalities that make QT interval corrected (QTc)
evaluation difficult.
- Prior exposure to a pyrrolobenzodiazepine or indolinobenzodiazepine based drug.
We found this trial at
7
sites
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University of California at Los Angeles The University of California, Los Angeles (UCLA) is an...
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660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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