Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

Inclusion Criteria:

1. Subject is healthy as judged by the Investigator based on all available assessments
from the Screening Period (e.g., safety laboratory, vital signs, physical examination,
ECG, concomitant medications and medical history).

2. Subject smokes on average four days a week for the last 12 months.

3. Subject has no intention of quitting smoking within the next 90 days.

4. Owns a smart phone with text message and data capabilities.

5. Willingness to use and ability to operate e-cigarettes.

6. Willingness to smoke Research Cigarettes.

Exclusion Criteria:

1. Any medical or psychiatric condition (or associated symptoms or medications)
determined by a medical professional to be severe enough to be disruptive to the
study.

2. Severe or uncontrolled psychiatric disease with the exception of anxiety disorders,
obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder
(ADHD);

3. Pregnant or nursing (by self-report) or positive pregnancy test;

4. Daily use of:

1. Experimental (investigational) drugs that are unknown to subject;

2. Smokeless tobacco (chewing tobacco, snuff), cigars, pipes and hookah;

3. e-cigarettes;

5. Use in the past 30 days of nicotine replacement therapy or other smoking cessation
product

6. Positive drug screen for cocaine