A Dose Finding Study Followed by a Safety and Efficacy Study for Patients With Multiple Myeloma or Lymphoma

Background and Rationale:

• TAS4464 is an investigational NEDD8 activating enzyme (NAE) inhibitor, a compound which may
affect cancer cell growth and survival. Thus, TAS4464 may help in the treatment of cancer.

Phase 1:

Primary:

- To investigate the safety and tolerability of TAS4464

- To identify a tolerated dose of TAS4464

Secondary:

- To investigate the preliminary efficacy of TAS4464

- To investigate the pharmacokinetics (PK) and the pharmacogenomics (PGx) of TAS4464

- To investigate the pharmacodynamics of TAS4464

Phase 2:

Primary:

• To investigate the efficacy of TAS4464

Secondary:

• To further investigate the safety profile of TAS4464

Inclusion Criteria:

1. Provide written informed consent

2. Women of child-bearing potential must have a negative pregnancy test

Multiple Myeloma:

Confirmed diagnosis of Multiple Myeloma with measurable disease, having been treated with
at least two prior lines of therapy.

Lymphoma:

Confirmed diagnosis of Non-Hodgkin Lymphoma with measurable disease, having been treated
with at least one anthracycline-based therapy, with relapse or progression since the last
treatment received.

Exclusion Criteria:

1. Any of the following treatments, within the specified time frame, prior to the first
dose of TAS4464:

1. Major surgery within 28 days

2. Radiation/chemotherapy within 21 days

3. Monoclonal antibodies within 28 days

4. Corticosteroid administration >20 mg/day of prednisone or equivalent within 14
days

5. Proteasome inhibitors within 14 days

6. Immunomodulatory agents within 7 days

7. Stem cell transplant within 3 months

8. Current immunosuppressive treatment for graft versus host disease

9. Current use of an investigational agent

2. Active graft versus host disease

3. Known serious illness or medical condition

4. Prior treatment with TAS4464 or known hypersensitivity to any of its inactive
ingredients or drugs similar in class

5. Pregnant or breast-feeding female