Macular Pigment Measurements in Eye & Other Tissues
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 7 - Any |
| Updated: | 10/14/2018 |
| Start Date: | June 2015 |
| End Date: | June 2025 |
| Contact: | Paul S. Bernstein, MD, PhD |
| Email: | Paul.Bernstein@hsc.utah.edu |
| Phone: | 801-581-4069 |
The purpose of this study is to understand the role of nutrition and its effects on the eye
and other tissues. The investigators propose to study this by validating and correlating
various non-invasive measurement methods of carotenoid concentrations in the human eye and
skin tissue.
A secondary objective is to correlate blood levels of carotenoids on a sub-set of
participants.
and other tissues. The investigators propose to study this by validating and correlating
various non-invasive measurement methods of carotenoid concentrations in the human eye and
skin tissue.
A secondary objective is to correlate blood levels of carotenoids on a sub-set of
participants.
The macula of the human retina (the structure responsible for high acuity vision essential
for reading, driving and recognizing faces) is colored an intense yellow due to the
deposition of two carotenoid compounds, lutein and zeaxanthin. These xanthophyll carotenoids
are derived exclusively from the diet, and are hypothesized to protect the macula from
light-induced oxidative damage by virtue of their light-screening and antioxidant properties.
Epidemiological studies have shown that high dietary intake and blood levels of lutein and
zeaxanthin are associated with lower rates of vision loss due to age-related macular
degeneration (AMD).
It is of interest to correlate carotenoid levels in the eye and skin tissues with blood
levels of carotenoid compounds.
for reading, driving and recognizing faces) is colored an intense yellow due to the
deposition of two carotenoid compounds, lutein and zeaxanthin. These xanthophyll carotenoids
are derived exclusively from the diet, and are hypothesized to protect the macula from
light-induced oxidative damage by virtue of their light-screening and antioxidant properties.
Epidemiological studies have shown that high dietary intake and blood levels of lutein and
zeaxanthin are associated with lower rates of vision loss due to age-related macular
degeneration (AMD).
It is of interest to correlate carotenoid levels in the eye and skin tissues with blood
levels of carotenoid compounds.
Inclusion Criteria:
- Any patient age 7 or older, undergoing routine dilated ophthalmology examinations at
the Moran Eye Center will be eligible to participate.
- Patients with adult vitelliform dystrophy. (This condition initially presents in
adulthood as bilateral subtle and often asymptomatic macular lesions, which are often
misdiagnosed as early age-related macular degeneration (AMD)).
Exclusion Criteria:
- Patients under age 7 will not be eligible to participate.
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