Intravenous Lidocaine Randomized Comparative Effectiveness Trial

Inclusion Criteria:Eligible patients are those who present to an ED for treatment of acute
abdominal pain. Acute will be defined as pain for no more than seven days. At the time of
enrollment, the ED treatment plan must include use of an intravenous opioid.

Exclusion Criteria: Patients will be excluded from participation if they have cardiac
conduction system impairment (QTc duration > 0.5s, QRS duration > 0.12s, or PR interval
duration > 0.2s), known renal (CKD >2) or liver disease (Childs-Pugh B or greater), are
hemodynamically unstable, as determined by the attending physician, are pregnant or
breastfeeding, or have a known allergy to either medication. Patients will also be excluded
if they have used prescription or illicit opioids within the previous week, or if they have
a chronic pain disorder, defined as use of any analgesic medication on more days than not
during the month preceding the acute episode of pain. Patients weighing < 60kg or > 120kg
will be excluded.