A Study of Cell Therapy for Subjects With Acute Kidney Injury Who Are Receiving Continuous Renal Replacement Therapy

Inclusion Criteria:

- AKI, as determined by the Investigator based on his/her clinical judgment

- Able to tolerate indwelling intravascular access

- Has tolerated Continuous Renal Replacement Therapy for at least 12 hours prior to IP
treatment

- Likely to require Continuous Renal Replacement Therapy for at least an additional 48
hours

- Ability to give informed consent

Exclusion Criteria:

- Female subjects who are pregnant, planning to become pregnant, or lactating

- Known end-stage liver disease

- Hepatorenal syndrome

- Acute glomerulonephritis (e.g. rapidly progressive glomerulonephritis;
membranoproliferative glomerulonephritis; post-streptococcal glomerulonephritis);
acute interstitial nephritis (e.g. toxin- or drug- induced interstitial nephritis) or
hereditary renal disease (e.g. Alport's Syndrome; polycystic kidney disease)

- AKI due to post-renal outflow obstruction

- Acute or chronic vasculitis of any etiology

- At the time of randomization, clinical evidence (e.g. febrile) suggestive of an
uncontrolled or inadequately treated systemic infection

- History of a chronic systemic infection of any etiology regardless of therapy

- Active malignancy(-ies) and/or receiving active treatment for a malignancy(-ies), with
the exception of non-melanoma skin cancer

- Subjects, who in the opinion of the Investigator, are likely to require escalating
doses of vasopressors to attain and/or maintain hemodynamic stability

- Systemic immunosuppressive therapy that has not been stabilized for greater than 4
months, or in the case of chronic corticosteroid therapy, a dose of >15 mg/day of
prednisone or the equivalent within the past 30 days

- Organ failure affecting more than 2 non-renal organs

- Platelet count <25,000/uL or other serious hematological abnormalities that would
place subject in imminent danger of death

- Any prior medical condition that, in the judgment of the Investigator, would prevent
the subject from safely participating in and/or completing all study requirements