Bioavailability Study of SPARC001(Study 1) in Healthy Adult Volunteers

Inclusion Criteria:

1. Adult, male and female volunteers, 18 to 55 years of age, inclusive, at first Check-In
Visit;

2. Body mass index (BMI) ≥18 to ≤30 kg/m2 and total body weight >50 kg (110 lbs) at
Screening

3. All female subjects must have a negative serum pregnancy test at Screening and at each
Check-in Visit

4. Medically healthy on the basis of medical history

Exclusion Criteria:

1. Females who are pregnant, lactating, or likely to become pregnant during the study

2. Life-time history and/or recent evidence of alcohol or drug/substance abuse disorder

3. Subjects with history or presence of significant cardiovascular, pulmonary, hepatic,
gallbladder or biliary tract, renal, hematologic, gastrointestinal, endocrine,
immunologic, dermatologic, neurologic, psychiatric disease, or active sexually
transmitted disease

4. Subjects determined by the investigator to have any medical condition that could
jeopardize their health or prejudice the results