LYmphangiogenesis FacTors in Heart Failure States
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 99 |
| Updated: | 3/2/2019 |
| Start Date: | May 18, 2017 |
| End Date: | June 2020 |
| Contact: | Renee Baxley, RN, BSN |
| Email: | baxleyr@musc.edu |
| Phone: | 843-792-1105 |
LYmphangiogenesis FacTors in Heart Failure States (LYFT-HF Study)
Heart failure often causes fluid to accumulate in the body, leading to congestion and
swelling. However, some people who have had heart failure for a long time seem to have very
little congestion or swelling, even when the heart failure is poorly treated. The
investigators think that this is because lymphatic vessels are able to grow and remove fluid
to prevent congestion. The investigators do not know how lymphatic vessels grow. This study
will investigate the blood levels of various proteins to try to figure out how the lymph
vessels of people with long-standing heart failure might grow.
swelling. However, some people who have had heart failure for a long time seem to have very
little congestion or swelling, even when the heart failure is poorly treated. The
investigators think that this is because lymphatic vessels are able to grow and remove fluid
to prevent congestion. The investigators do not know how lymphatic vessels grow. This study
will investigate the blood levels of various proteins to try to figure out how the lymph
vessels of people with long-standing heart failure might grow.
Inclusion Criteria:
- Undergoing clinically indicated right heart catheterization.
Exclusion Criteria:
- Unable to provide consent.
- Use of medications which may alter lymphangiogenesis factor expression within 365 days
- Thalidomide, lenalidomide, pomalidomide
- Bevacizumab
- Any cytotoxic chemotherapy agents
- Pregnant
- Any potentially pregnant patient (based on age and gender) undergoes Beta Human
chorionic gonadotropin testing as standard of care prior to any right heart
catheterization.
- Active cancer within 365 days
- Diagnosis of familial or secondary lymphedema
- Treatment of active bacterial infection within 7 days
- Active inflammatory rheumatologic disease requiring anti-inflammatory therapy
administration within 60 days
- Conditions
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Scleroderma
- Inflammatory myositis
- Vasculitis
- Behcet's disease
We found this trial at
2
sites
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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