CRF - Nociceptin Receptor Interactions
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 9/8/2018 |
| Start Date: | June 1, 2016 |
| End Date: | June 1, 2019 |
| Contact: | Rajesh Narendran |
| Email: | narendranr@upmc.edu |
In Vivo Imaging of Corticotropin-releasing Factor - Nociceptin Receptor Interactions
To determine if [C-11]NOP-1A receptor binding (VT) can be altered by an intravenous
hydrocortisone (cortisol) challenge through CRF-NOP interactions
hydrocortisone (cortisol) challenge through CRF-NOP interactions
Examines changes in [C-11]NOP-1A pharmacokinetics caused by an intravenous hydrocortisone
challenge (1 mg/kg)
challenge (1 mg/kg)
Inclusion Criteria:
- Males or females between 18 and 40 years old
Exclusion Criteria:
- Current DSM-5 psychiatric disorders
- Binge drinking as defined in NIAAA criteria in the past month
- Recreational abuse of opiates, sedative-hypnotics, cocaine, amphetamines, MDMA, and
PCP, as well as cannabis use
- Currently on any prescription medical or psychotropic medication;
- Current or past severe medical, endocrine, cardiovascular, immunological or
neurological illnesses
- Currently pregnant or breast-feeding;
- History of radioactivity exposure via prior nuclear medicine studies or occupational
exposure in past twelve months
- Metallic objects in the body that are contraindicated for MRI;
- First-degree relative with psychosis or mood disorders
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