Oral Microbiome and Pancreatic Cancer
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Cancer, Pancreatic Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 55 - 74 |
| Updated: | 10/8/2017 |
| Start Date: | December 1, 1992 |
| End Date: | December 1, 2010 |
Oral Microbiome and Pancreatic Cancer: a Prospective Case-Control Study
This is a prospective population based study to examine the relationship of oral and
pancreatic microbiome, and their functions, to pancreatic cancer risk.
The identification of specific oral bacteria and their functional relationship to pancreatic
cancer will advance scientific knowledge on the etiology of pancreatic cancer. This could
provide a new microbially-based research paradigm, possibly leading to new drug targets for
this disease. Second, the oral bacteria may serve as a readily accessible, non-invasive
biomarker for subsequent pancreatic cancer risk, which help to identify people at high risk
of this disease. Finally, the identified oral bacteria may lead to microbial prophylactic
preventions, with antibiotic therapy aimed at eradicating the specific species associated
with increased cancer risk or, alternatively, combined with probiotics to introduce species
that are associated with a decreased cancer risk. Thus, the study outcomes will lead to
actionable means for pancreatic cancer prevention.
pancreatic microbiome, and their functions, to pancreatic cancer risk.
The identification of specific oral bacteria and their functional relationship to pancreatic
cancer will advance scientific knowledge on the etiology of pancreatic cancer. This could
provide a new microbially-based research paradigm, possibly leading to new drug targets for
this disease. Second, the oral bacteria may serve as a readily accessible, non-invasive
biomarker for subsequent pancreatic cancer risk, which help to identify people at high risk
of this disease. Finally, the identified oral bacteria may lead to microbial prophylactic
preventions, with antibiotic therapy aimed at eradicating the specific species associated
with increased cancer risk or, alternatively, combined with probiotics to introduce species
that are associated with a decreased cancer risk. Thus, the study outcomes will lead to
actionable means for pancreatic cancer prevention.
A history of periodontal disease and the presence of circulating antibodies to selected oral
pathogens have been associated with increased risk of pancreatic cancer; however, direct
relationships of oral microbes with pancreatic cancer have not been evaluated in prospective
studies. Investigators examine the relationship of oral microbiota with subsequent risk of
pancreatic cancer in a large nested case-control study.
pathogens have been associated with increased risk of pancreatic cancer; however, direct
relationships of oral microbes with pancreatic cancer have not been evaluated in prospective
studies. Investigators examine the relationship of oral microbiota with subsequent risk of
pancreatic cancer in a large nested case-control study.
Inclusion Criteria:
- DNA extracted from oral wash samples from NIH-PLCO and ACS-CPS cohorts
Exclusion Criteria:
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