Low Dose Vasopressin in Traumatic Shock
Status: | Terminated |
---|---|
Conditions: | Hospital |
Therapuetic Areas: | Other |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 12/14/2017 |
Start Date: | February 2007 |
End Date: | February 2011 |
Prospective, Randomized, Double-Blind, Multi-Center Trial of Low Dose Vasopressin Versus Placebo in Traumatic Shock Resuscitation
Hypothesis: We hypothesize that resuscitation regimens which minimize the total volume of
resuscitation fluid, while restoring organ perfusion, will lead to lower morbidity and
mortality in critically ill patients following trauma.
resuscitation fluid, while restoring organ perfusion, will lead to lower morbidity and
mortality in critically ill patients following trauma.
Inclusion Criteria:
To be eligible for enrollment in the study, a patient must meet all of the follow criteria
at assessment:
- Patient is a male or female patient presumed to be at least 18 years of age;
- Patient has a systolic blood pressure < 90 mmHg;
- Patient has clinical evidence of acute traumatic injury;
- Infusion of study drug must start within one hour following SBP < 90 mmHg
Exclusion Criteria:
A patient meeting any one of the following criteria at hospital assessment is not eligible
for enrollment:
- Patient is admitted to one of the study hospitals' Emergency Department greater than
six hours after injury;
- Patient has received greater than 4 liters fluid since time of injury;
- Patient is enrolled in another shock trial;
- Patient is asystolic or requires CPR prior to randomization;
- Female patient is pregnant by report or suspicion;
- Patient has known "Do Not Resuscitate" orders or visible/identifiable method of
objection to participation (e.g., exclusion bracelet);
We found this trial at
1
site
4502 Medical Drive
San Antonio, Texas 78284
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
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