Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil
| Status: | Completed |
|---|---|
| Conditions: | Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 10/8/2017 |
| Start Date: | February 2009 |
| End Date: | May 2010 |
A Pilot Study of Prolonged, Intermittent Exposure to Alfentanil on Opioid-Induced Hyperalgesia in Healthy Volunteers
The purpose of this study was to follow a person's response to experimental pain after
multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can
tolerate the pain more, less, or the same at the end of the study.
multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can
tolerate the pain more, less, or the same at the end of the study.
This project investigates the phenomenon of opioid-induced hyperalgesia (OIH). Opioid
analgesics, in addition to their therapeutic anti-nociceptive effects, under some conditions
produce pro-nociceptive effects. This phenomenon of pain or pain sensitivity being increased
by prior opioid administration is called opioid-induced hyperalgesia. It is thought to be
relevant both to pain management complications and to complications of opioid dependence and
its treatment. This study investigated the time-course of opioid-induced hyperalgesia
development in healthy normal volunteers (N=12 completers), using a series of acute
alfentanil administrations (15 mg/kg mg intramuscular (IM) per day) spaced at 3-4 day
intervals, with testing for pain tolerance using the cold pressor test (CPT), and mechanical
quantitative sensory testing (MQST) each administered repeatedly over time within each
testing day. The goal was to determine the time course of OIH development following acute
opioid administration, and to assess whether this changes over repeated acute opioid
administrations.
analgesics, in addition to their therapeutic anti-nociceptive effects, under some conditions
produce pro-nociceptive effects. This phenomenon of pain or pain sensitivity being increased
by prior opioid administration is called opioid-induced hyperalgesia. It is thought to be
relevant both to pain management complications and to complications of opioid dependence and
its treatment. This study investigated the time-course of opioid-induced hyperalgesia
development in healthy normal volunteers (N=12 completers), using a series of acute
alfentanil administrations (15 mg/kg mg intramuscular (IM) per day) spaced at 3-4 day
intervals, with testing for pain tolerance using the cold pressor test (CPT), and mechanical
quantitative sensory testing (MQST) each administered repeatedly over time within each
testing day. The goal was to determine the time course of OIH development following acute
opioid administration, and to assess whether this changes over repeated acute opioid
administrations.
Inclusion Criteria:
- Age 18-55
- No active medical conditions
- BMI between 20-30
- Able and willing to perform/tolerate pain procedures
- Able to communicate in English
Exclusion Criteria:
- Lifetime substance use disorder, except for alcohol abuse/dependence in remission
- Use of opiates in last 3 months
- Ongoing marijuana use
- Acute or chronic pain
- Neurologic or psychiatric condition known to influence cold pressor testing
(peripheral neuropathy, major depression, or schizophrenia)
- Current use of prescribed or over the counter pain medications
- Previous adverse reaction to opiate medications or diphenhydramine
- Use of tobacco or caffeine on study days
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