Genetic Basis of Melanocytic Nevi
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/26/2019 |
| Start Date: | June 26, 2017 |
| End Date: | April 1, 2019 |
| Contact: | Maija Kiuru, MD |
| Email: | mkiuru@ucdavis.edu |
| Phone: | 916-734-0591 |
The objective of this protocol is to further elucidate the genetic mutations that drive
melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole
genome, whole exome, or targeted sequencing of de-identified specimens.
Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and
blood samples:
1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the
tissue will be submitted for routine diagnostic dermatopathology and investigational
histomorphologic and immunohistochemical analysis.
2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a
normal control when analyzing sequencing data to identify somatic mutations in lesional
tissue.
melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole
genome, whole exome, or targeted sequencing of de-identified specimens.
Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and
blood samples:
1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the
tissue will be submitted for routine diagnostic dermatopathology and investigational
histomorphologic and immunohistochemical analysis.
2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a
normal control when analyzing sequencing data to identify somatic mutations in lesional
tissue.
Inclusion criteria:
- Male or female subjects that are 18 years or older
- Subjects with melanocytic nevi\
Exclusion criteria:
- Patients less than 18 years of age
- Patients without melanocytic nevi
- Patients with a bleeding disorder or are taking anticoagulation medication
We found this trial at
1
site
Sacramento, California 95816
Phone: 916-734-1509
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