Multi-Parametric MRI for Renal Transplantation

To achieve these goals, the investigators will perform pilot MRI studies with kidney
transplant patients. The investigators will study if MRI can reflect different levels of
kidney function. The investigators will also evaluate if MRI can differentiate causes for
declining kidney function. Finally, the investigators will explore how MRI measures changes
before and after medical treatment for worsening kidney function.

Subjects may be invited for MRI exams with different exam options. An MRI exam may use either
of two types of MRI machines at the CMRR: the 3T scanner and the 7T scanner. Subjects may
also be invited for a multi-session exam. A description of the MRI exam types with different
exam options and the types of multi-session exams is provided later in this document.

Inclusion Criteria:

- Renal Transplant Recipients

- Capable to consent

- English speaking

- For studies with patients with fast worsening renal function: An abrupt (within 48 h)
reduction in kidney function currently defined as a percentage increase in serum
creatinine of ≥50% (1.5-fold from baseline), or a reduction in urine output
(documented oliguria of less than 0.5 mL/kg/h for more than 6 h).

- For patients with recovered renal allograft function after therapy: renal allograft
function as measured by eGRF has been recovered and stabilized above a clinical
acceptable level, such as 15 ml/min/1.73 mm2.

Exclusion Criteria:

- On dialysis due to renal allograft failure

- Acute and chronic pulmonary disease

- Pregnancy as reported in CMRR Safety Screen

- Ferromagnetic implants

- Any foreign metal objects in the body

- History of shrapnel or shot gun injury

- Cardiac pacemakers

- Defibrillator

- Neuronal stimulator

- Magnetic aneurysm clip

- Large tattoos on the abdomen or the brain and neck, as determined by CMRR Safety
Officer

- Hip replacement

- Too large to fit in the magnet (BMI >= 40, approx.)

- Severe claustrophobia