Evaluation of the Efficacy and Tolerability of Clobetasol Propionate Foam Compared to Vehicle Foam

The purpose of the study is to compare the efficacy and safety of Clobetasol propionate to
that of its Vehicle in the treatment of mild to moderate plaque-type psoriasis. This is a
multi-center, double blind, randomized, parallel designed study which consists of 2 weeks of
treatment and a follow-up visit 2 weeks later.

Inclusion Criteria:

- Outpatient, male or female of any race, and at least 12 years of age. Female subjects
of childbearing potential must have a negative urine pregnancy test result at baseline
and practice a reliable method of contraception throughout the study.

- Mild to moderate, plaque-type psoriasis

- Target lesion on the trunk or extremities (excluding palms/soles, elbows, or knees)
with a score of 2 or 3 for each of erythema, scaling and plaque thickness

- Able to understand the requirements of the study and sign Informed Consent/HIPAA
Authorization Forms. Subjects under the legal age of consent in the state where the
study is conducted must also have the written, informed consent of a parent or legal
guardian.

Exclusion Criteria:

- Female subjects who are pregnant (positive urine pregnancy test) breast feeding or who
are of childbearing potential and not practicing a reliable method of birth control

- Known allergy to clobetasol propionate or other topical corticosteroids; or to any
component of the investigational formulations

- Subjects who have not complied with the proper wash-out periods for prohibited
medications

- Medical condition that in the opinion of the investigator, contraindicates the
subject's participation in the clinical study

- Skin disease/disorder that might interfere with the study related diagnosis or
evaluations

- Evidence of recent alcohol or drug abuse

- History of poor cooperation, non-compliance with medical treatment or unreliability