Cerebral MRI During Sleep
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 59 |
| Updated: | 3/16/2019 |
| Start Date: | October 1, 2017 |
| End Date: | October 31, 2018 |
Recent studies in animal models have suggested a critical role for cerebrospinal fluid and
Interstitial fluid flux through cerebral parenchyma for removal of byproducts of cellular
metabolism and hence in maintaining the health of the brain. This effect is modulated during
sleep, suggesting a potentially important mechanism for sleep to maintain both acute
homeostasis and long-term cerebral health.
The central goal of these studies is to develop a sensitive MRI biomarker of cerebral
conformational changes during sleep. This exploratory work aims to establish the sensitivity
and reproducibility of MRI as a non-invasive neuroimaging assessment of cerebral changes
during natural sleep and sedation.
Interstitial fluid flux through cerebral parenchyma for removal of byproducts of cellular
metabolism and hence in maintaining the health of the brain. This effect is modulated during
sleep, suggesting a potentially important mechanism for sleep to maintain both acute
homeostasis and long-term cerebral health.
The central goal of these studies is to develop a sensitive MRI biomarker of cerebral
conformational changes during sleep. This exploratory work aims to establish the sensitivity
and reproducibility of MRI as a non-invasive neuroimaging assessment of cerebral changes
during natural sleep and sedation.
Recent studies in animal models have suggested a critical role for cerebrospinal fluid (CSF)
/ Interstitial fluid (ISF) flux through cerebral parenchyma for removal of byproducts of
cellular metabolism and hence in maintaining the health of the brain. It remains unknown to
what extent these phenomena exist in the human brain. A key challenge in this work is to make
non-invasive and reproducible measurements of the cerebral microenvironment in humans. For
these studies, the investigators have implemented a suite of MRI measurements to track
physiological changes in the brain during sleep. This exploratory work aims to establish the
sensitivity and reproducibility of MRI as a non-invasive neuroimaging assessment of cerebral
changes during natural sleep and sedation. The long term goal of this work is to use MRI as
an imaging biomarker to assess the cerebral response to normal versus disordered sleep in
patients.
Our specific aims will address the following questions:
Aim 1: How sensitive are MRI metrics for determining changes in the brain during sleep?
Aim 2: How reproducible are MRI metrics during sleep and during sedation?
The investigators will recruit 12 normal adult subjects for this study (consecutive
respondees to recruitment adverts). The investigators will make regional MRI measurements
during onset, maintenance and waking from stage N2 sleep. From these the investigators will
characterize which MRI metrics are most sensitive to changes in the cerebral environment, and
how these vary for different cerebral regions.
Measurements will be repeated during ~90 minutes of natural sleep, and following oral
sedation with 10 mg zaleplon (Sonata).
/ Interstitial fluid (ISF) flux through cerebral parenchyma for removal of byproducts of
cellular metabolism and hence in maintaining the health of the brain. It remains unknown to
what extent these phenomena exist in the human brain. A key challenge in this work is to make
non-invasive and reproducible measurements of the cerebral microenvironment in humans. For
these studies, the investigators have implemented a suite of MRI measurements to track
physiological changes in the brain during sleep. This exploratory work aims to establish the
sensitivity and reproducibility of MRI as a non-invasive neuroimaging assessment of cerebral
changes during natural sleep and sedation. The long term goal of this work is to use MRI as
an imaging biomarker to assess the cerebral response to normal versus disordered sleep in
patients.
Our specific aims will address the following questions:
Aim 1: How sensitive are MRI metrics for determining changes in the brain during sleep?
Aim 2: How reproducible are MRI metrics during sleep and during sedation?
The investigators will recruit 12 normal adult subjects for this study (consecutive
respondees to recruitment adverts). The investigators will make regional MRI measurements
during onset, maintenance and waking from stage N2 sleep. From these the investigators will
characterize which MRI metrics are most sensitive to changes in the cerebral environment, and
how these vary for different cerebral regions.
Measurements will be repeated during ~90 minutes of natural sleep, and following oral
sedation with 10 mg zaleplon (Sonata).
Inclusion Criteria:
- Healthy Adults
Exclusion Criteria:
1. age not in range 18-59
2. smoking / recreational drug use
3. pregnant women / breast feeding
4. contraindication to MRI
5. contraindications to Zaleplon
6. history of cardiovascular pulmonary or cerebral disease (hypertension (diastolic >90
mmHg, systolic > 150 mmHg), unstable cerebrovascular syndromes, prior history of
cardiac arrhythmias, unstable angina, chronic obstructive pulmonary disease).
7. Current SSRI antidepressant medication
8. History of sleep disorder or currently taking sedative / stimulant medication
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