Evaluation of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo

Inclusion Criteria:

- Age between 18 and 85 years

- History of, or at high risk for, cardiovascular disease (CVD) including coronary
artery disease, symptomatic peripheral arterial disease, cerebrovascular
atherosclerotic disease, or at high risk for a cardiovascular event

- Patient reported history of statin intolerance (inability to tolerate 2 or more
statins, one at a low dose)

- Men and nonpregnant, nonlactating women

- Fasting blood LDL-cholesterol ≥ 100 (2.6 mmol/L) at screening

Exclusion Criteria:

- Fasting blood triglycerides greater than 500 mg/dL (5.6 mmol/L) at screening

- Recent (within 90 days of screening) history of major cardiovascular events, transient
ischemic attack (TIA), or unstable or symptomatic cardiac arrhythmia

- History of severe heart failure

- Uncontrolled hypertension or uncontrolled diabetes