Study Evaluating CMC-544 In B-Cell Non-Hodgkin's Lymphoma



Status:Completed
Conditions:Lymphoma, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 99
Updated:12/19/2018
Start Date:August 2003
End Date:December 2010

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 1 Study Of Cmc-544 Administered As A Single Agent In Subjects With B-cell Non- Hodgkin's Lymphoma

To determine the Maximum Tolerated Dose (MTD), the tolerability, and the initial safety
profile of CMC-544 in subjects with B-cell Non-Hodgkin's Lymphoma (NHL).


Inclusion Criteria:

- Subjects who have been previously diagnosed with CD22-positive, B-cell NHL, according
to WHO classification, which has progressed after at least 2 prior therapies of
probable clinical benefit

- At the expanded cohort, part 2 of the study, subjects must have one of the following:

- Follicular lymphoma previously treated with at least one dose of rituximab, but have
not received radioimmunotherapy

- Diffuse large B-cell lymphoma

- Age 18 years or older

Exclusion Criteria:

- Candidate for potentially curative therapies in the opinion of the investigator

- Chronic lymphocytic leukemia

- Burkitt's lymphoma, primary effusion lymphoma, and precursor B-cell lymphoblastic
lymphoma
We found this trial at
12
sites
Northwestern Memorial Hospital
251 E Huron St
Chicago, Illinois 60611
(312) 926-2000
Northwestern Memorial Hospital Northwestern Memorial is an academic medical center hospital where the patient comes...
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University of Alabama at Birmingham
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
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Birmingham, AL
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Roswell Park Cancer Institute
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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UAB CCC Clinical Studies Unit
Birmingham, Alabama 35233
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Birmingham, AL
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University of Alabama at Birmingham, The Kirklin Clinic
Birmingham, Alabama 35233
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UAB Russell Ambulatory Pharmacy
Birmingham, Alabama 35294
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Northwestern Medical Faculty Foundation
Chicago, Illinois 60611
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Chicago, IL
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Cleveland Clinic Foundation
2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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Cleveland, OH
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M.D. Anderson Cancer Center
Houston, Texas 77030
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Houston, TX
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Universitair Ziekenhuis Gasthuisberg
Leuven,
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Leuven,
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Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
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Philadelphia, PA
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Univ of Pennsylvania
3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Philadelphia, PA
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