Study Evaluating HKI-272 in Tumors
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/19/2018 |
| Start Date: | November 2003 |
| End Date: | January 2007 |
An Ascending Single and Multiple Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HKI-272 Administered Orally to Subjects With HER-2/NEU or HER-1/EGFR-Positive Tumors
The purpose of this study is to evaluate the safety and tolerability as well as find the
maximum tolerated dose (MTD) for HKI-272. In addition, this study will examine the effects of
the study drug on your tumor, and how your body uses and eliminates HKI-272.
maximum tolerated dose (MTD) for HKI-272. In addition, this study will examine the effects of
the study drug on your tumor, and how your body uses and eliminates HKI-272.
Inclusion Criteria:
- Her2/neu or Her1/EGFR positive cancer
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
- Measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST)
Exclusion Criteria:
- Prior treatment with anthracyclines with a cumulative dose of doxorubicin or
equivalent of greater than 300 mg/m^2
- Patients with significant cardiac risk factors
- Active central nervous system metastasis
We found this trial at
5
sites
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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12902 USF Magnolia Dr
Tampa, Florida 33612
Tampa, Florida 33612
(888) 663-3488
H. Lee Moffitt Cancer Center & Research Institute Moffitt Cancer Center in Tampa, Florida, has...
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Sarah Cannon Cancer Center People who live with cancer
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660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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