Study for Using Radiosurgery on Limited Metastases of Breast Cancer

Before treatment begins, you will have a physical exam and blood tests. Physical evaluations
and blood tests will be done each week while you are receiving treatment, and at follow-up
visits. You will be seen for follow-up evaluations 4 weeks after treatment is completed, and
every three months thereafter. You will be asked to fill out a Quality of Life questionnaire,
which should take 5-10 minutes to complete. This will be done prior to treatment and at your
follow-up visits. You will receive high dose radiation therapy directed at the site of
metastasis. This treatment will be given once a day, 5 times a week (Monday through Friday)
for one to four weeks depending on the location and size of the disease to be treated.

Inclusion Criteria:

- Age: no limit

- Karnofsky performance status (KPS) ≥ 70

- No more than 5 metastatic sites involving one or more different organs (liver, lung or
bone).

- The size of the lesion must be such that it can be safely treated to sterilizing
radiation doses according to the rules in the protocol.

- Previously treated lesions are not eligible unless the prescribed dose can be safely
delivered.

- Concurrent therapy is allowed and recommended. The chemotherapy protocol type and
schedule are at the discretion of the medical oncologist.

- Informed consent must be obtained.

- Pregnancy test must be negative for women of child bearing potential

Exclusion Criteria:

- Inability of patient to be followed longitudinally as specified by protocol.

- Technical inability to achieve required dose based on safe dose constraints required
for radiosurgery.

- Women who are pregnant or nursing.

- Failure to meet requirements in Inclusion Criteria

- Contraindications to radiation.