PPAR-gamma Agonists, Rheumatoid Arthritis and Cardiovascular Disease
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Peripheral Vascular Disease, Rheumatoid Arthritis |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Rheumatology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | November 2007 |
| End Date: | July 2012 |
| Contact: | Rita P Hench, BS,CCRC |
| Email: | rhench@umich.edu |
| Phone: | 734-998-7045 |
Peroxisome Proliferator-activated Receptor-gamma Agonists, Rheumatoid Arthritis and Cardiovascular Disease
Patients with rheumatoid arthritis have a significantly higher risk to develop heart attacks
and other complications of their blood vessels. New therapies are needed to prevent this
complication. The purpose of this study is to establish the role of the medication
pioglitazone in improving the function of the blood vessels and heart and decreasing the
risk of future atherosclerosis development in individuals with rheumatoid arthritis. As a
secondary aim-point, we will evaluate the efficacy of pioglitazone in improving rheumatoid
arthritis disease activity and markers of inflammation.
This study will establish the role of pioglitazone in improvement of endothelial function,
arterial compliance and disease activity in patients with rheumatoid arthritis. This will be
a placebo-controlled, double blind, cross-over trial.
Inclusion Criteria:
- Women on adequate contraception if they are of child-bearing age.
- Meet revised ACR criteria for RA.
- Stable doses of DMARDS,biologic agents and or corticosteroids for at least 3 months.
Exclusion Criteria:
- Pregnant or lactating women.
- Current smokers or individuals who smoked in the last 6 months.
- Diagnosis of Diabetes, heart failure, or infection.
- Current diagnosis of malignant disease except for basal cell or squamous cell
carcinoma of the skin.
- No active liver disease.
- No cholesterol-lowering medications or oral hypoglycemic agents.
We found this trial at
1
site
Click here to add this to my saved trials
