ACT34-CMI -- Adult Autologous CD34+ Stem Cells
| Status: | Completed |
|---|---|
| Conditions: | Angina, Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 21 - 80 |
| Updated: | 10/22/2017 |
| Start Date: | March 2006 |
| End Date: | March 2009 |
A Double-blind, Prospective, Randomized, Placebo-controlled Study to Determine the Tolerability, Efficacy, Safety, and Dose Range of Intramyocardial Injections of G-CSF Mobilized Auto--CD34+ Cells for Reduction of Angina Episodes in Patients With Refractory Chronic Myocardial Ischemia (ACT34-CMI)
The purpose of this study is to evaluate the efficacy and safety of intramyocardial
injections of adult stem cells in patients with refractory chronic myocardial ischemia.
injections of adult stem cells in patients with refractory chronic myocardial ischemia.
This is a double-blind, prospective, randomized, placebo-controlled trial to determine the
tolerability, efficacy, safety and dose range of intramyocardial injections of adult
autologous CD34+ cells mobilized with granulocyte colony stimulating factor for the reduction
of angina episodes in patients with refractory chronic myocardial ischemia.
tolerability, efficacy, safety and dose range of intramyocardial injections of adult
autologous CD34+ cells mobilized with granulocyte colony stimulating factor for the reduction
of angina episodes in patients with refractory chronic myocardial ischemia.
Inclusion Criteria:
- 21-80 years of age
- CCS functional class III or IV chronic refractory angina
- unsuitable for conventional revascularization
Exclusion Criteria:
- predominant congestive heart failure
- left ventricular ejection fraction of less than 25% at screening
- myocardial infarction within 60 days of treatment
- successful coronary revascularization within 6 months of study enrollment
- history of moderate to severe aortic stenosis or prosthetic aortic valve
- co-morbidity associated with life expectancy of less than 1 year
We found this trial at
26
sites
University Hospitals of Cleveland The history of University Hospitals Case Medical Center is linked to...
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University of Cincinnati Medical Center Opening in 1823 as the country
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University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
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Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Florida Hospital Florida Hospital is one of the country
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University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
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Swedish Medical Center Since 1910, Swedish has been the region's hallmark for excellence in health...
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110 Irving St NW
Washington, District of Columbia 20010
Washington, District of Columbia 20010
(202) 877-7000
Washington Hosp Ctr MedStar Washington Hospital Center is a not-for-profit, 926-bed, major teaching and research...
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