Assessment of Coronary Artery Disease by Hybrid PET/CT

Advances in Non-invasive Multislice CT Imaging: Multislice CT (MSCT) and PET imaging are
becoming more widely available and more useful in cardiac assessment. MSCT provides
quantification of coronary calcium as well as information about the structures of the
coronary vessel walls and atherosclerotic plaques. Multiple studies have demonstrated that
MSCT provides information on coronary artery stenosis comparable to that obtained from
invasive coronary angiography. PET imaging provides functional data via the measurement of
coronary flow reserve (CFR). CFR is a quantitative measure of the increase in coronary blood
flow in response to vasodilation; normal coronary flow is able to augment by three- to
four-fold; diseased coronary arteries show less ability to increase flow, i.e. less CFR.
Assessment of CFR yields functional information about the significance of coronary disease
and is often used clinically in conjunction with anatomic imaging to identify early
atherosclerosis. There is no current data evaluating the incremental value of hybrid PET/CT
assessment of CFR and coronary anatomy in relation to SPECT studies in the clinical setting.

Inclusion Criteria:

- Subject must be 18 years of age or older and able to give informed consent.

- Scheduled for clinically indicated gated Adenoscan SPECT studies at the University of
Maryland Medical Center or Baltimore VA Center

- Documentation from participant's health care provider indicating no objection to
subject's participation in study.

Exclusion Criteria:

- Hepatic; thyroid or renal disease (creatinine >1.5 or GFR < 60mL/min)

- Women of childbearing age not using medically acceptable form of contraception,
pregnant or breast-feeding

- Contrast allergy

- Inability to cooperate with imaging