TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine

Inclusion Criteria:

- Consented males and nonpregnant females using adequate contraception, between 18 and
55 years of age, with at least 1-6 migraines per month for past 6 months. Subjects
will be excluded for confirmed or suspected ischemic heart disease, uncontrolled
hypertension at screening; a history of epilepsy or structural brain lesions which
lowered the convulsive threshold; confirmed or suspected cardiovascular,
cerebrovascular, peripheral vascular, congenital heart disease, or ischemic bowel
disease; impaired hepatic or renal function; basilar or hemiplegic migraine. Other
exclusion criteria included use of a monoamine oxidase inhibitor within 2 weeks before
screening; ergot prophylactics in past 3 months; anticoagulants; smoking more than 10
cigarettes/day, evidence of alcohol or substance abuse; GI bleeding disorders,
inflammatory bowel disease; or any concurrent medical or psychiatric condition that in
the investigator's opinion could affect interpretation of efficacy or safety
information or which otherwise contraindicated participation in the study.