Imaging Study of Chronic Low Back Pain in Patients Taking Pain Medication
| Status: | Completed |
|---|---|
| Conditions: | Back Pain, Back Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 12/13/2017 |
| Start Date: | September 2006 |
| End Date: | January 2010 |
Functional MRI Neural Correlates of Medication Efficacy in Patients With Chronic Low Back Pain
Duloxetine has recently been shown to be effective in reducing the pain in chronic pain
patients. Duloxetine is known to exert a central mechanism, however the precise human brain
structures responsible for mediating its pain-relieving properties are not known. We will use
functional magnetic resonance imaging (FMRI) to investigate the neural and functional
correlates of pain.
patients. Duloxetine is known to exert a central mechanism, however the precise human brain
structures responsible for mediating its pain-relieving properties are not known. We will use
functional magnetic resonance imaging (FMRI) to investigate the neural and functional
correlates of pain.
Inclusion Criteria:- Males aged 18-60
- Back Pain
- Must be able to comply with study visit schedule and other study requirements
- Capable of performing the experimental tasks
Exclusion Criteria:- Contraindications for MRI examination (e.g., metallic implants such as
pacemakers, surgical aneurysm clips, or known metal fragments embedded in the body)
- Known hypersensitivity to duloxetine or any of the inactive ingredients
- Uncontrolled narrow-angle glaucoma
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