ORTHOVISC Shoulder Osteoarthritis Study

This multicenter, prospective double-blinded, randomized trial will study two treatment
groups. Subjects will be randomized to receive either Orthovisc or corticosteroids/anesthetic
injection into the shoulder in a 2:1 schema. The trial will assess safety and efficacy of
pain relief in the osteoarthritic shoulder.

Inclusion Criteria:

- A candidate for unilateral treatment of osteoarthritis of the shoulder

- Have failed conservative treatment

Exclusion Criteria:

- Presence of full thickness Rotator Cuff tear and/or significantly compromised rotator
cuff function

- No active instability or acute dislocation episodes within the previous 12 months

- Known allergy to hyaluronate preparations

- Pregnant or breast feeding

- Is receiving prescription pain medication for conditions unrelated to the index
shoulder condition