A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 10/14/2017 |
| Start Date: | May 2006 |
| End Date: | May 2009 |
A Comparison Study of the Efficacy of a Rapid Titration of Quetiapine and Haloperidol in Agitated Adults in an Emergency Setting.
In the Psychiatric Emergency Room, agitated patients are treated routinely with an I.M.
Haloperidol "cocktail" (Haloperidol 5 mg, Lorazepam 2 mg, Cogentin 2 mg), which has proved to
be an effective treatment. However, since it is an intramuscular injection, it is more
complicated and perhaps less acceptable to patients as well as more likely to cause EPS
(extrapyramidal symptoms). Of late in our emergency room, we started using high dose
Quetiapine 300 mg PO to replace the "cocktail" for treating agitation. It has shown promising
results.
This study is designed to compare the efficacy and safety of Quetiapine with the routine
"cocktail for treatment of agitation.
The primary purpose of this study is to determine the efficacy and safety of Quetiapine by
using high dose Quetiapine (300 mg) PO to treat agitated patients in the psychiatric
emergency room.
The secondary purpose is to test the immediate effect on agitation caused by illicit drug
abuse or the alcohol abuse.
Haloperidol "cocktail" (Haloperidol 5 mg, Lorazepam 2 mg, Cogentin 2 mg), which has proved to
be an effective treatment. However, since it is an intramuscular injection, it is more
complicated and perhaps less acceptable to patients as well as more likely to cause EPS
(extrapyramidal symptoms). Of late in our emergency room, we started using high dose
Quetiapine 300 mg PO to replace the "cocktail" for treating agitation. It has shown promising
results.
This study is designed to compare the efficacy and safety of Quetiapine with the routine
"cocktail for treatment of agitation.
The primary purpose of this study is to determine the efficacy and safety of Quetiapine by
using high dose Quetiapine (300 mg) PO to treat agitated patients in the psychiatric
emergency room.
The secondary purpose is to test the immediate effect on agitation caused by illicit drug
abuse or the alcohol abuse.
Inclusion Criteria:
1. English or Spanish speaking patients
2. Provision of written informed consent-English and Spanish
3. Males and females age 18 to 60 years. Females who are pregnant by inspection should
not be included.
4. Provision at diagnosis meeting the Diagnostic and Statistical Manual of Mental
Disorder, 4th edition (DSM-IV) criteria for Axis I documented who present in an
agitated state. PANSS-EC score should be >15.
5. Ability, in the treating physician's opinion, to co-operate with taking oral
medication
Exclusion Criteria:
1. Pregnant females who will thus receive routine care in the treating physician's
opinion
2. Unstable medical illness
3. Withdrawal stage from any illicit drugs
4. Psychosis that prohibits participation in trial
5. Females of childbearing age where pregnancy cannot be confirmed or denied by screening
6. Patients who required continued intervention or prolonged restraint
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