Effect of Budesonide on Exhaled Nitric Oxide in Asthmatic Children
| Status: | Completed |
|---|---|
| Conditions: | Asthma |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 4 - 6 |
| Updated: | 10/14/2017 |
| Start Date: | August 2007 |
| End Date: | January 2009 |
Phase IV Study of the Effect of Nebulized Budesonide on Exhaled Nitric Oxide in Children, Four to Six Years of Age, With Asthma
To study the improvement in airway inflammation in children with asthma non-invasively with
exhaled breath NO, a marker of inflammation, after therapy with nebulized budesonide as 0.5mg
daily.
exhaled breath NO, a marker of inflammation, after therapy with nebulized budesonide as 0.5mg
daily.
Comparisons will be made before and after 2 week therapy of nebulized budesonide in children
not on prior anti-inflammatory medications.
not on prior anti-inflammatory medications.
Inclusion Criteria:
- Asthma diagnosis previously for 6 months
- Past asthma medication without change for previous 6 months
- Increased NO levels and ability to perform maneuver
- ICF signed by parents
Exclusion Criteria:
- Systemic steroids in past 60 days,inhaled/nebulized steroids in past 4 weeks
- Hospitalization within 3 months
- Upper or lower airways active infection or cigarette smoke direct exposure
- Use of other asthma medications other than bronchodilators one month prior and during
the trial
- Noncompliance
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