Brain Dopamine Function in Adults With ADHD

Inclusion Criteria:

- Must give informed consent

- Must be between the ages of 18 and 45 years old.

- Must have a confirmed diagnosis of ADHD

- Must have scored on a rating scale that indicate a significant level of symptom
severity.

- Must have a childhood history of ADHD must be documented using established test
criteria.

- Must have had no previous medication treatment for ADHD except for a short term
treatment period of less than three months, which should have occurred at least six
months prior to the study.

- Must have an interest in receiving long-term medication treatment for ADHD.

Exclusion Criteria:

- Must not test positive for psychoactive drugs during a urine drug screen.

- Must not be pregnant.

- Must not be breastfeeding.

- Must have no past or present history of dependence on alcohol or other drugs of abuse
except nicotine or caffeine.

- Must have no past or present history of a psychiatric disorder except ADHD.

- Must have no medical illness that may affect brain function.

- Must not have taken medication that may affect brain function.

- Must not have had head trauma with loss of consciousness (> 30 minutes).

- Must not have significant anxiety or depression as determined by an established test.

- Must have no history of a significant learning disability.

- Must have no history of cardiovascular or endocrinological disease.

- Must have no history of coagulation disorder.

- Must have no history of sensitivity to lidocaine and/or prilocaine.

- Must have no history of claustrophobia.

- Contraindication to MRI environment (presence of any implanted metallic objects such
as cardiac/neural pacemakers, defibrillators, aneurysm clips, certain heart valves,
spinal nerve stimulators, artificial joints/limbs, shrapnel/bullets, metal fragments
in their eyes, cochlear implants, hearing aids, dental implants).

- Must have no history of glaucoma.