Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Hospital, Gastrointestinal |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 19 - 80 |
| Updated: | 10/14/2017 |
| Start Date: | April 2008 |
| End Date: | October 2012 |
Effects of Inhaled Nitric Oxide on Ischemia-Reperfusion Injury in Human Liver During Transplantation
This blinded, placebo-controlled study will administer inhaled nitric oxide to patients
undergoing liver transplantation. The purpose of the study is to test if inhaled nitric oxide
prevents liver injury associated with the restoration of blood flow. The premise of the
current study is provided by previous studies which document a protective effect of inhaled
nitric oxide in this clinical setting.
undergoing liver transplantation. The purpose of the study is to test if inhaled nitric oxide
prevents liver injury associated with the restoration of blood flow. The premise of the
current study is provided by previous studies which document a protective effect of inhaled
nitric oxide in this clinical setting.
Specifically, presenting ischemia-reperfusion injury to transplanted livers remains a
therapeutic goal in improving liver function and potentially expanding the number of
transplantable livers. This study aims to assess the efficacy of inhaled nitric oxide to
limit ischemia-reperfusion injury in transplanted livers and by doing so improve liver
function post transplantation and decrease patient hospital length of stays.
therapeutic goal in improving liver function and potentially expanding the number of
transplantable livers. This study aims to assess the efficacy of inhaled nitric oxide to
limit ischemia-reperfusion injury in transplanted livers and by doing so improve liver
function post transplantation and decrease patient hospital length of stays.
Inclusion Criteria:
- Patients > 19 yr of age scheduled to undergo liver transplantation.
Exclusion Criteria:
- Patients < 19 yr of age
- Patients undergoing re-transplantation or dual organ transplantation
- Patients with underlying pulmonary complications
We found this trial at
2
sites
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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