Parcopa Versus Carbidopa-Levodopa in a Single Dose Cross-Over Comparison Study

Inclusion Criteria:

- Male or female between the age of 31 and 80 -Diagnosis of idiopathic Parkinson's
disease for at least three years duration

- Patients requiring levodopa for their PD

- Good subjective response to levodopa

- Fluctuating symptoms defined by wearing off phenomenon, any dyskinesia, and/or dose
failures

- A UPDRS -off- motor score of at least 25

- Subjects willing to give informed consent

- Subjects who are able and willing to comply with study procedures

- If female of child-bearing potential, will use one of the approved birth control
measures:

1. Hormonal contraceptives

2. Spermicidal and barrier

3. Intrauterine device

4. Partner sterility

Exclusion Criteria:

- Subjects with evidence of significant dementia

- Subjects with significant oral lesions

- History of unstable cardiac disease including angina or congestive heart failure
within 3 months prior to study entry

- History of clinically significant renal disease including renal insufficiency of
sufficient degree to require adjunctive treatment or dietary restrictions

- History of clinically significant hepatic disease, including previously documented
cirrhosis or hepatic insufficiency or jaundice within 3 months prior to study entry.

- Subjects with poor response to levodopa

- Women who are pregnant, breast-feeding, or planning to become pregnant during this
study are excluded from participation due to unknown effects of the study drug on the
fetus.